Article

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

2019-07-15

Abstract excerpt

Myeloid-derived suppressor cells (MDSCs) are innate immune cells that acquire the capacity to suppress adaptive immune responses during cancer. It remains elusive how MDSCs differ from their normal myeloid counterparts, which limits our ability to specifically detect and therapeutically target MDSCs during cancer. Here, we used single-cell RNAseq to compare MDSC-containing splenic myeloid cells from breast tumor-b...

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Literature Corpus work: eb5bbb37-9284-54ad-be37-39b83a8bdfd8
DOI: 10.1101/702860

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