Fitness landscape of substrate-adaptive mutations in evolved amino acid-polyamine-organocation transporters.

Abstract excerpt

The emergence of new protein functions is crucial for the evolution of organisms. This process has been extensively researched for soluble enzymes, but it is largely unexplored for membrane transporters, even though the ability to acquire new nutrients from a changing environment requires evolvability of transport functions. Here, we demonstrate the importance of environmental pressure in obtaining a new activity...

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