Article
Mutations in global regulators lead to metabolic selection during adaptation to complex environments.
PLoS genetics - 1 Dec 2014
Saxer Gerda, Krepps Michael D, Merkley Eric D, Ansong Charles, Deatherage Kaiser Brooke L, Valovska Marie-Thérèse, Ristic Nikola, Yeh Ping T, Prakash Vittal P, Leiser Owen P, Nakhleh Luay, Gibbons Henry S, Kreuzer Helen W, Shamoo Yousif
Abstract excerpt
Adaptation to ecologically complex environments can provide insights into the evolutionary dynamics and functional constraints encountered by organisms during natural selection. Adaptation to a new environment with abundant and varied resources can be difficult to achieve by small incremental cha...
Topics
- Adaptation, Biological
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Citric Acid Cycle
- Citrobacter freundii
- Escherichia coli
- Escherichia coli Proteins
- Evolution, Molecular
- Gastrointestinal Tract
- Gene Expression Regulation, Bacterial
- Gene-Environment Interaction
- Genetic Variation