Article
Molecular-functional studies of adaptive genetic variation in prokaryotes and eukaryotes.
Annual review of genetics - 1 Jan 2000
Watt W B, Dean A M
Abstract excerpt
Knowledge of both prokaryotic and eukaryotic organisms is essential to the study of molecular evolution. Their common ancestry mandates that their molecular functions share many aspects of adaptation and constraint, yet their differences in size, ploidy, and structural complexity also give rise to divergent evolutionary options. We explore the interplay of adaptation, constraint, and neutrality in their evolution...
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