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Article

A genetic mouse model mimicking MET related human osteofibrous dysplasia is characterized by delays in fracture repair and defective osteogenesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 31 Jul 2024

Hong Guoju, Xie William, Ahmed Kashif, Oborn Connor, Soltys Carrie-Lynn, Kannu Peter

Abstract excerpt

Osteofibrous dysplasia (OFD) is a rare, benign, fibro-osseous lesion that occurs most commonly in the tibia of children. Tibial involvement leads to bowing and predisposes to the development of a fracture which exhibit significantly delayed healing processes, leading to prolonged morbidity. We previously identified gain-of-function mutations in the MET gene as a cause for OFD. In our present study, we test the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39042586
DOI: 10.1096/fj.202400075RR

Genes

MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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