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Article

Genetic intratumour heterogeneity and clonal evolution in extramammary Paget's disease.

European journal of dermatology : EJD - 1 Apr 2024

Tanaka Kenichiro, Kajihara Ikko, Shimokawa Kazuro, Nakamura Naotoshi, Kusaba Yudo, Sakamoto Ryoko, Maeda-Otsuka Saki, Yamada-Kanazawa Saori, Sawamura Soichiro, Kanemaru Hisashi, Makino Katsunari, Aoi Jun, Masuguchi Shinichi, Suzuki Takashi, Fukushima Satoshi

Abstract excerpt

All tumour cells in a patient have shared and non-shared genetic alterations, and the diversity of mutations is described as intratumoural heterogeneity (ITH). Multiregion sequencing is a genome sequencing analytical technique used for multiple, spatially-separated biopsy tissues that may further our understanding of ITH and tumour evolution. Although genetic mutations in extramammary Paget's disease (EMPD) have...

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PMID: 38907549
DOI: 10.1684/ejd.2024.4609

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