Article
Genetic landscape of indolent and aggressive Kaposi sarcomas.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Dec 2022
Malouf G G, Lu X, Mouawad R, Spano J-P, Grange P, Yan F, Aractingi S, Su X, Dupin N
Abstract excerpt
BACKGROUND: Kaposi sarcoma (KS) is a rare skin tumour caused by herpesvirus 8 infection and characterized by either indolence or an aggressive course necessitating systemic therapies. The genetic basis of this difference remains unknown. OBJECTIVES: To explore the tumour mutational burden in indolent and aggressive KS. METHODS: We performed whole-exome sequencing on a cohort of 21 KS patients. We compared genetic...
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