Article
Multiregional Sequencing Reveals Genomic Alterations and Clonal Dynamics in Primary Malignant Melanoma of the Esophagus.
Cancer research - 15 Jan 2018
Li Jingjing, Yan Shi, Liu Zhen, Zhou Yong, Pan Yaqi, Yuan WenQin, Liu Mengfei, Tan Qin, Tian Geng, Dong Bin, Cai Hong, Wu Nan, Ke Yang
Abstract excerpt
Primary malignant melanoma of the esophagus (PMME) is a rare and aggressive disease with high tendency of metastasis. To characterize the genetic basis and intratumor heterogeneity of PMME, we performed multiregion exome sequencing and whole genome SNP array genotyping of 12 samples obtained from a patient with PMME. High intratumor heterogeneity was observed in both somatic mutation and copy-number alteration...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.