Unbiased Detection of Driver Mutations in Extramammary Paget Disease.

doi:10.1158/1078-0432.CCR-20-3205

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Article

Unbiased Detection of Driver Mutations in Extramammary Paget Disease.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2021

Ishida Yoshihiro, Kakiuchi Nobuyuki, Yoshida Kenichi, Inoue Yoshikage, Irie Hiroyuki, Kataoka Tatsuki R, Hirata Masahiro, Funakoshi Takeru, Matsushita Shigeto, Hata Hiroo, Uchi Hiroshi, Yamamoto Yuki, Fujisawa Yasuhiro, Fujimura Taku, Saiki Ryunosuke, Takeuchi Kengo, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Otsuka Atsushi, Miyano Satoru, Kabashima Kenji, Ogawa Seishi

Abstract excerpt

PURPOSE: Extramammary Paget disease (EMPD) is an uncommon skin malignancy whose genetic alterations are poorly characterized. Previous reports identified mutations in chromatin remodeling genes and PIK3CA. In order to unambiguously determine driver mutations in EMPD, we analyzed 87 EMPD samples using exome sequencing in combination with targeted sequencing. EXPERIMENTAL DESIGN: First, we analyzed 37 EMPD samples...

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PMID: 33323405
DOI: 10.1158/1078-0432.CCR-20-3205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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