Article
Association of genetic alterations with prognosis in extramammary Paget disease: insights into the involvement of somatic CDKN2A variants in patients with a poor prognosis.
The British journal of dermatology - 23 Dec 2024
Iwasawa Okuto, Ikegami Masachika, Miyagawa Takuya, Morita Hiromichi, Saito Hinako, Omori Issei, Awaji Kentaro, Omatsu Jun, Yamada Daisuke, Kage Hidenori, Oda Katsutoshi, Sato Shinichi, Sumida Hayakazu
Abstract excerpt
BACKGROUND: Previous studies have reported the mutational landscape in extramammary Paget disease (EMPD); however, the prognostic implications of genetic alterations remain unexplored. While CDKN2A loss is known to be associated with tumour progression or poor prognosis in some types of cancer, its significance in EMPD has not been investigated. OBJECTIVES: To examine the association between common genetic...
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