Article
Analysis of genomic and immune intratumor heterogeneity in linitis plastica via multiregional exome and T-cell receptor sequencing.
Molecular oncology - 1 Aug 2023
Huang Jin, Zhao Guofeng, Peng Qiu, Yi Xin, Ji Liyan, Li Jing, Li Pansong, Guan Yanfang, Ge Jie, Chen Ling, Chen Runzhe, Hu Xin, Lee Won-Chul, Reuben Alexandre, Futreal P Andrew, Xia Xuefeng, Ma Jian, Zhang Jianjun, Chen Zihua
Abstract excerpt
The molecular landscape and the intratumor heterogeneity (ITH) architecture of gastric linitis plastica (LP) are poorly understood. We performed whole-exome sequencing (WES) and T-cell receptor (TCR) sequencing on 40 tumor regions from four LP patients. The landscape and ITH at the genomic and immunological levels in LP tumors were compared with multiple cancers that have previously been reported. The lymphocyte...
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