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Article

Genomic landscape of multiple Bowen's disease using whole-exome sequencing.

The Journal of dermatology - 1 Mar 2023

Kim Yoon-Seob, Park Gyeong Sin, Bang Chul Hwan, Chung Yeun-Jun

Abstract excerpt

The genomic landscape of Bowen's disease (BD), with multiple manifestations, has not yet been determined. This study aimed to investigate the genomic alterations in multiple BD. We performed whole-exome sequencing of BD lesions (n = 9) and matched germlines collected from three patients with multiple (≥3) BD to detect somatic and germline mutations. We found a median of 64 somatic mutations in each sample (range...

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PMID: 36117467
DOI: 10.1111/1346-8138.16584

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