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Article

A Broad-specificity Neutralizing Nanobody against Hepatitis E Virus Capsid Protein.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2024

Wang Xueting, Sheng Yamin, Ji Pinpin, Deng Yingying, Sun Yani, Chen Yiyang, Nan Yuchen, Hiscox Julian A, Zhou En-Min, Liu Baoyuan, Zhao Qin

Abstract excerpt

Hepatitis E virus (HEV) is a worldwide zoonotic and public health concern. The study of HEV biology is helpful for designing viral vaccines and drugs. Nanobodies have recently been considered appealing materials for viral biological research. In this study, a Bactrian camel was immunized with capsid proteins from different genotypes (1, 3, 4, and avian) of HEV. Then, a phage library (6.3 × 108 individual clones)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38905108
DOI: 10.4049/jimmunol.2300706
PMCID: PMC11299488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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