Article

Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants

2022-04-27

Abstract excerpt

Significance Due to their small size, nanobodies can recognize protein cavities that are not accessible to conventional antibodies. In this report, we built dromedary camel ( Camelus dromedarius ) V H H phage libraries for the isolation of high-affinity nanobodies that broadly neutralize SARS-CoV-2 variants. Cryo-EM complex structures reveal that one dromedary camel V H H nanobody (8A2) binds the S1 subunit of the...

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Literature Corpus work: a30a5367-eb6c-5eac-9c02-4ba3a9dcb38f
DOI: 10.1073/pnas.2201433119

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