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Article

Additional impact of genetic ancestry over race/ethnicity to prevalence of KRAS mutations and allele-specific subtypes in non-small cell lung cancer.

HGG advances - 18 Jul 2024

Wang Xinan, Hou Kangcheng, Ricciuti Biagio, Alessi Joao V, Li Xihao, Pecci Federica, Dey Rounak, Luo Jia, Awad Mark M, Gusev Alexander, Lin Xihong, Johnson Bruce E, Christiani David C

Abstract excerpt

The KRAS mutation is the most common oncogenic driver in patients with non-small cell lung cancer (NSCLC). However, a detailed understanding of how self-reported race and/or ethnicity (SIRE), genetically inferred ancestry (GIA), and their interaction affect KRAS mutation is largely unknown. Here, we investigated the associations between SIRE, quantitative GIA, and KRAS mutation and its allele-specific subtypes in...

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Identifiers

PMID: 38902927
DOI: 10.1016/j.xhgg.2024.100320
PMCID: PMC11452329

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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