Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancers.

doi:10.1016/j.ccell.2023.10.003

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Article

Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancers.

Cancer cell - 13 Nov 2023

Jiagge Evelyn, Jin Dexter X, Newberg Justin Y, Perea-Chamblee Tomin, Pekala Kelly R, Fong Christopher, Waters Michele, Ma David, Dei-Adomakoh Yvonne, Erb Gilles, Arora Kanika S, Maund Sophia L, Njiraini Njoki, Ntekim Atara, Kim Susie, Bai Xuechun, Thomas Marlene, van Eeden Ronwyn, Hegde Priti, Jee Justin, Chakravarty Debyani, Schultz Nikolaus, Berger Michael F, Frampton Garrett M, Sokol Ethan S, Carrot-Zhang Jian

Abstract excerpt

Cancer genomes from patients with African (AFR) ancestry have been poorly studied in clinical research. We leverage two large genomic cohorts to investigate the relationship between genomic alterations and AFR ancestry in six common cancers. Cross-cancer type associations, such as an enrichment of MYC amplification with AFR ancestry in lung, breast, and prostate cancers, and depletion of BRAF alterations are...

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Identifiers

PMID: 37890492
DOI: 10.1016/j.ccell.2023.10.003
PMCID: PMC11097212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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