Article

Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations

2020-09-02

Abstract excerpt

Inherited lung cancer risk, particularly in non-smokers, is poorly understood. Genomic and ancestry analysis of 1,153 lung cancers from Latin America revealed striking associations between Native American ancestry and their somatic landscape, including tumor mutational burden (TMB), and specific driver mutations in EGFR, KRAS , and STK11 . A local Native American ancestry risk score predicted EGFR and KRAS mutatio...

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Literature Corpus work: b77f4629-1920-54ca-b531-620a0765b922
DOI: 10.1101/2020.09.01.20183913

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