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Article

Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations.

Cancer discovery - 1 Mar 2021

Carrot-Zhang Jian, Soca-Chafre Giovanny, Patterson Nick, Thorner Aaron R, Nag Anwesha, Watson Jacqueline, Genovese Giulio, Rodriguez July, Gelbard Maya K, Corrales-Rodriguez Luis, Mitsuishi Yoichiro, Ha Gavin, Campbell Joshua D, Oxnard Geoffrey R, Arrieta Oscar, Cardona Andres F, Gusev Alexander, Meyerson Matthew

Abstract excerpt

Inherited lung cancer risk, particularly in nonsmokers, is poorly understood. Genomic and ancestry analysis of 1,153 lung cancers from Latin America revealed striking associations between Native American ancestry and their somatic landscape, including tumor mutational burden, and specific driver mutations in EGFR, KRAS, and STK11. A local Native American ancestry risk score was more strongly correlated with EGFR...

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Identifiers

PMID: 33268447
DOI: 10.1158/2159-8290.CD-20-1165
PMCID: PMC7933062

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