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Article

Variation in targetable genomic alterations in non-small cell lung cancer by genetic ancestry, sex, smoking history, and histology.

Genome medicine - 15 Apr 2022

Adib Elio, Nassar Amin H, Abou Alaiwi Sarah, Groha Stefan, Akl Elie W, Sholl Lynette M, Michael Kesi S, Awad Mark M, Jӓnne Pasi A, Gusev Alexander, Kwiatkowski David J

Abstract excerpt

BACKGROUND: Genomic alterations in 8 genes are now the targets of FDA-approved therapeutics in non-small cell lung cancer (NSCLC), but their distribution according to genetic ancestry, sex, histology, and smoking is not well established. METHODS: Using multi-institutional genetic testing data from GENIE, we characterize the distribution of targetable genomic alterations in 8 genes among 8675 patients with NSCLC...

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Identifiers

PMID: 35428358
DOI: 10.1186/s13073-022-01041-x
PMCID: PMC9013075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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