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Tracing unknown tumor origins with a biological-pathway-based transformer model

1 Jun 2024

Abstract excerpt

Cancer of unknown primary (CUP) represents metastatic cancer where the primary site remains unidentified despite standard diagnostic procedures. To determine the tumor origin in such cases, we developed BPformer, a deep learning method integrating the transformer model with prior knowledge of biological pathways. Trained on transcriptomes from 10,410 primary tumors across 32 cancer types, BPformer achieved...

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PMID: 38889685
DOI: 10.1016/j.crmeth.2024.100797

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