Article

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions

2020-08-12

Abstract excerpt

Sporadic angiosarcomas (ASs) are aggressive vascular sarcomas whose rarity and genomic complexity present significant obstacles in deciphering the pathogenic significance of individual genetic alterations. Numerous fusion genes have been identified across multiple types of cancers, but their existence and significance remain unclear in sporadic ASs. In this study, we leveraged RNA sequencing data from thirteen hum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce9a19e4-f98f-56b5-b20d-0a43ab4ee30a
DOI: 10.1101/2020.08.11.246777

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene FusionsDOI 10.1101/2020.08.11.246777Read

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene FusionsSemantic proximity Read

Molecular subtypes in canine hemangiosarcoma reveal similarities with human angiosarcoma.Semantic proximity Read

Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human AngiosarcomaSemantic proximity Read

Comparison of the oncogenomic landscape of canine and feline hemangiosarcoma shows novel parallels with human angiosarcoma.Semantic proximity Read

Real-world evidence couples genomic biomarkers with therapeutic outcomes for canine hemangiosarcomaSemantic proximity Read

Genomic analysis reveals shared genes and pathways in human and canine angiosarcomaSemantic proximity Read

Recurrent CIC Gene Abnormalities in Angiosarcomas: A Molecular Study of 120 Cases With Concurrent Investigation of PLCG1, KDR, MYC, and FLT4 Gene Alterations.Semantic proximity Read

Genomic landscapes of canine splenic angiosarcoma (hemangiosarcoma) contain extensive heterogeneity within and between patients.Semantic proximity Read

Genomic landscapes of canine splenic angiosarcoma (hemangiosarcoma) contain extensive heterogeneity within and between patientsSemantic proximity Read

Identification of genomic alterations with clinical impact in canine splenic hemangiosarcomaSemantic proximity Read

Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humansSemantic proximity Read

The genetics of vascular tumours: an update.Semantic proximity Read