Consistent <i>MYC</i> and <i>FLT4</i> gene amplification in radiation‐induced angiosarcoma but not in other radiation‐associated atypical vascular lesions

Abstract excerpt

Angiosarcoma (AS) is a distinct group of sarcomas characterized by upregulation of vascular-specific receptor tyrosine kinases, including TIE1, KDR, TEK, and FLT1. In keeping with the clinical heterogeneity, gene-expression profiling distinguishes two AS genomic clusters, which correlate with anatomical location and prior exposure to radiation. Furthermore, a high percentage of secondary AS, but not primary AS,...

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