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The effect of apolipoprotein E genotype on spatial processing in humans: A meta-analysis and systematic review.

Cortex; a journal devoted to the study of the nervous system and behavior - 1 Aug 2024

Daly Jessica, De Luca Flavia, Berens Sam C, Field Andy P, Rusted Jennifer M, Bird Chris M

Abstract excerpt

The ε4 allele of the apolipoprotein E (APOE4) gene is an established risk factor for Alzheimer's disease but its impact on cognition in healthy adults across the lifespan is unclear. One cognitive domain that is affected early in the course of Alzheimer's disease is spatial cognition, yet the evidence for APOE-related changes in spatial cognition is mixed. In this meta-analysis we assessed the impact of carrying...

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PMID: 38878339
DOI: 10.1016/j.cortex.2024.05.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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