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Prevalence and clinical significance of germline pathogenic variants identified by multigene panel testing in high-risk Japanese patients with breast cancer.

Breast cancer (Tokyo, Japan) - 1 Jul 2026

Kano Miharu, Taruno Kanae, Inuzuka Mayuko, Makino Reiko, Takeuchi Mieko, Suzuki Misato, Kida Kumiko, Takei Junko, Nagayama Aiko, Hayashida Tetsu, Haruyama Yurie, Ueno Takayuki, Watanabe Chie, Kojima Yasuyuki, Sasai Rumi, Endo Mikiko, Momozawa Yukihide, Nakamura Seigo

Abstract excerpt

BACKGROUND: In Japan, BRCA genetic testing for the diagnosis of hereditary breast and ovarian cancer is covered by medical insurance. However, other breast cancer (BC) susceptibility genes are rarely examined in these patients, primarily because medical insurance does not cover testing for these genes. METHODS: A multigene panel testing (MGPT) was conducted on patients with BC who met the clinical criteria for...

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PMID: 42126782
DOI: 10.1007/s12282-026-01863-2
PMCID: PMC13283129

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BRCA1

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