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Article

Interleukin-1 Receptor Antagonist Gene (IL1RN) Variants Modulate the Cytokine Release Syndrome and Mortality of COVID-19.

The Journal of infectious diseases - 14 Jun 2024

Attur Mukundan, Petrilli Christopher, Adhikari Samrachana, Iturrate Eduardo, Li Xiyue, Tuminello Stephanie, Hu Nan, Chakravarti Aravinda, Beck David, Abramson Steven B

Abstract excerpt

BACKGROUND: We examined effects of single-nucleotide variants (SNVs) of IL1RN, the gene encoding the anti-inflammatory interleukin 1 receptor antagonist (IL-1Ra), on the cytokine release syndrome (CRS) and mortality in patients with acute severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. METHODS: IL1RN CTA haplotypes formed from 3 SNVs (rs419598, rs315952, rs9005) and the individual SNVs were...

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Source

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Identifiers

PMID: 38871359
DOI: 10.1093/infdis/jiae031
PMCID: PMC11175666

Genes

IL1RN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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