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Article

Genetic Implication of Prenatal GABAergic and Cholinergic Neuron Development in Susceptibility to Schizophrenia.

Schizophrenia bulletin - 27 Aug 2024

Cameron Darren, Vinh Ngoc-Nga, Prapaiwongs Parinda, Perry Elizabeth A, Walters James T R, Li Meng, O'Donovan Michael C, Bray Nicholas J

Abstract excerpt

BACKGROUND: The ganglionic eminences (GE) are fetal-specific structures that give rise to gamma-aminobutyric acid (GABA)- and acetylcholine-releasing neurons of the forebrain. Given the evidence for GABAergic, cholinergic, and neurodevelopmental disturbances in schizophrenia, we tested the potential involvement of GE neuron development in mediating genetic risk for the condition. STUDY DESIGN: We combined data...

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Identifiers

PMID: 38869145
DOI: 10.1093/schbul/sbae083
PMCID: PMC11349020

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