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Article

Single-Nuclei RNA Sequencing of 5 Regions of the Human Prenatal Brain Implicates Developing Neuron Populations in Genetic Risk for Schizophrenia.

Biological psychiatry - 15 Jan 2023

Cameron Darren, Mi Da, Vinh Ngoc-Nga, Webber Caleb, Li Meng, Marín Oscar, O'Donovan Michael C, Bray Nicholas J

Abstract excerpt

BACKGROUND: While a variety of evidence supports a prenatal component in schizophrenia, there are few data regarding the cell populations involved. We sought to identify cells of the human prenatal brain mediating genetic risk for schizophrenia by integrating cell-specific gene expression measures generated through single-nuclei RNA sequencing with recent large-scale genome-wide association study (GWAS) and exome...

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Identifiers

PMID: 36150908
DOI: 10.1016/j.biopsych.2022.06.033
PMCID: PMC10804933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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