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Article

Enrichment of schizophrenia heritability in both neuronal and glia cell regulatory elements.

Translational psychiatry - 10 Jan 2018

Tansey Katherine E, Hill Matthew J

Abstract excerpt

Genome-wide association studies have identified over 100 robust risk loci for schizophrenia with thousands of variants mediating genetic heritability, the majority of which reside in non-coding regions. Analytical approaches have shown this heritability is strongly enriched at variants within regulatory elements identified from human post-mortem brain tissue. However, bulk post-mortem brain tissue has a...

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PMID: 29317610
DOI: 10.1038/s41398-017-0053-y
PMCID: PMC5802526

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