Elucidating the causal associations and mechanisms between circulating immune cells and idiopathic pulmonary fibrosis: new insights from Mendelian randomization and transcriptomics.

Abstract excerpt

Background: Growing evidence indicates an association between circulating immune cell phenotypes and idiopathic pulmonary fibrosis (IPF). Although studies have attempted to elucidate the causal relationship between the two, further clarification of the specific mechanisms and causal linkages is warranted. Objective: We aimed to conduct a two-sample Mendelian randomization (MR) analysis with transcriptomics data...

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• Biomarkers
• Gene Expression Profiling
• Genome-Wide Association Study
• Idiopathic Pulmonary Fibrosis
• Mendelian Randomization Analysis