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Article

Chronic Obstructive Pulmonary Disease Influence on Lung Cancer Risk Through Blood Metabolite Mediation: A Two-Sample Mendelian Randomisation and Mediation Analysis.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Cao Yan-Nan, Wang Long, Fan Hu-Sen, Zhang Zhen-Jiang

Abstract excerpt

Purpose: Lung cancer (LC) risk is increased by chronic obstructive pulmonary disease (COPD) through metabolic and inflammatory processes. In addition to identifying possible inflammatory or blood metabolite mediators, this study explores the causal link between LC and COPD. Patients and Methods: To determine whether COPD and LC are causally related, as well as whether inflammatory variables and blood metabolites...

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Identifiers

PMID: 42367346
DOI: 10.2147/COPD.S608125
PMCID: PMC13295007

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