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Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules

10 Aug 2010

Abstract excerpt

Mutations in the RNA-binding protein FUS (fused in sarcoma) are linked to amyotrophic lateral sclerosis (ALS), but the mechanism by which these mutants cause motor neuron degeneration is not known. We report a novel ALS truncation mutant (R495X) that leads to a relatively severe ALS clinical phenotype compared with FUS missense mutations. Expression of R495X FUS, which abrogates a putative nuclear localization...

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PMID: 20699327
DOI: 10.1093/hmg/ddq335

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Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granulesPMID 20699327Read ↗

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