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Mutant FUS perturbs m 6 A regulation by repressing ALKBH5, while restoring m 6 A levels alleviates ALS pathology in vivo

2025-11-26

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder marked by the progressive loss of motor neurons, where aberrant stress granule (SG) dynamics has emerged as a hallmark, especially in cases involving mutations in RNA-binding proteins such as FUS and TDP-43. We previously showed that m 6 A RNA modification is elevated in FUS-associated ALS and that restoring its physiological levels through METTL...

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Literature Corpus work: ddb61d47-2384-57b0-aeb0-5e1891d541a9
DOI: 10.1101/2025.11.26.690809

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Mutant FUS perturbs m 6 A regulation by repressing ALKBH5, while restoring m 6 A levels alleviates ALS pathology in vivoDOI 10.1101/2025.11.26.690809Read

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Mutant FUS perturbs m <sup>6</sup> A regulation by repressing ALKBH5, while restoring m <sup>6</sup> A levels alleviates ALS pathology <i>in vivo</i>

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