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Article

Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes.

Epigenomics - 1 Sept 2018

Yang Chenchen, Stueve Theresa Ryan, Yan Chunli, Rhie Suhn K, Mullen Daniel J, Luo Jiao, Zhou Beiyun, Borok Zea, Marconett Crystal N, Offringa Ite A

Abstract excerpt

AIM: To identify functional lung adenocarcinoma (LUAD) risk SNPs. MATERIALS & METHODS: Eighteen validated LUAD risk SNPs (p ≤ 5 × 10-8) and 930 SNPs in high linkage disequilibrium (r2 > 0.5) were integrated with epigenomic information from primary human alveolar epithelial cells. Enhancer-associated SNPs likely affecting transcription factor-binding sites were predicted. Three SNPs were functionally investigated...

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Topics

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Share to Adenocarcinoma
Share to Alveolar Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Linkage Disequilibrium

Share to Lung Neoplasms

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 30212242
DOI: 10.2217/epi-2018-0003
PMCID: PMC6391636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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