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Article

Triple-cell lineage tracing by a dual reporter on a single allele.

The Journal of biological chemistry - 17 Jan 2020

Liu Kuo, Tang Muxue, Jin Hengwei, Liu Qiaozhen, He Lingjuan, Zhu Huan, Liu Xiuxiu, Han Ximeng, Li Yan, Zhang Libo, Tang Juan, Pu Wenjuan, Lv Zan, Wang Haixiao, Ji Hongbin, Zhou Bin

Abstract excerpt

Genetic lineage tracing is widely used to study organ development and tissue regeneration. Multicolor reporters are a powerful platform for simultaneously tracking discrete cell populations. Here, combining Dre-rox and Cre-loxP systems, we generated a new dual-recombinase reporter system, called Rosa26 traffic light reporter (R26-TLR), to monitor red, green, and yellow fluorescence. Using this new reporter system...

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Identifiers

PMID: 31771978
DOI: 10.1074/jbc.RA119.011349
PMCID: PMC6970925

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