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In-silico analysis of non-synonymous single nucleotide polymorphisms in human β-defensin type 1 gene reveals their impact on protein-ligand binding sites.

Computational biology and chemistry - 1 Jun 2022

Fareed Muhammad Mazhar, Ullah Sana, Aziz Shan, Johnsen Todd Axel, Shityakov Sergey

Abstract excerpt

Single nucleotide polymorphism (SNPs) is an important genetic biomarker to assess protein function and its possible contribution to genetic diseases, such as the β- defensin 1 gene (DEFB1)-associated non-synonymous SNPs (nsSNPs). Defensins are antimicrobial and immunomodulatory peptides, acting as part of innate immunity, and killing bacteria by interacting phosphatidylinositol 4,5-bisphosphate (PIP2). Therefore,...

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PMID: 35452998
DOI: 10.1016/j.compbiolchem.2022.107669

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