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Article

Mutations associated with in vitro resistance to bedaquiline in Mycobacterium tuberculosis isolates in Australia.

Tuberculosis (Edinburgh, Scotland) - 1 Jul 2018

Martinez Elena, Hennessy Daneeta, Jelfs Peter, Crighton Taryn, Chen Sharon C-A, Sintchenko Vitali

Abstract excerpt

Genome-wide analysis of 517 Mycobacterium tuberculosis isolates from New South Wales, Australia, have identified previously reported and 8 new mutations in Rv0678 and atpE genes linked to in vitro resistance to bedaquiline, a new class of antimycobacterial drugs. These mutations were present in 2.9% of prospectively sequenced genomes but in 10.6% of strains that were phenotypically multidrug-resistant. However...

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Identifiers

PMID: 30029911
DOI: 10.1016/j.tube.2018.04.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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