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The Molecular Mechanisms of Complement Receptor 1—It Is Complicated

13 Oct 2023

Abstract excerpt

Human complement receptor 1 (CR1) is a membrane-bound regulator of complement that has been the subject of recent attempts to generate soluble therapeutic compounds comprising different fragments of its extracellular domain. This review will focus on the extracellular domain of CR1 and detail how its highly duplicated domains work both separately and together to mediate binding to its main ligands C3b and C4b,...

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PMID: 37892204
DOI: 10.3390/biom13101522

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