Article
Deciphering Complement Receptor Type 1 Interactions with Recognition Proteins of the Lectin Complement Pathway
5 Mar 2013
Abstract excerpt
Complement receptor type 1 (CR1) is a membrane receptor expressed on a wide range of cells. It is involved in immune complex clearance, phagocytosis, and complement regulation. Its ectodomain is composed of 30 complement control protein (CCP) modules, organized into four long homologous repeats (A-D). In addition to its main ligands C3b and C4b, CR1 was reported to interact with C1q and mannan-binding lectin...
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