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C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions

23 May 2017

Abstract excerpt

and C1q binding to its ligands activates these two serine proteases. The classic C1q ligands are antigen-bound antibodies and activated C1s cleaves C4 and C2 to initiate the complement cascade. Recent studies suggest broad C1 functions beyond the complement system. C1q binds to the Frizzled receptors to activate C1s, which cleaves lipoprotein receptor-related protein 6 to trigger aging-associated Wnt receptor...

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PMID: 28596769
DOI: 10.3389/fimmu.2017.00592

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