Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium.

doi:10.1371/journal.pone.0185660

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Article

Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium.

PloS one - 1 Jan 2017

Wang Tao, Moon Jee-Young, Wu Yiqun, Amos Christopher I, Hung Rayjean J, Tardon Adonina, Andrew Angeline, Chen Chu, Christiani David C, Albanes Demetrios, Heijden Erik H F M van der, Duell Eric, Rennert Gadi, Goodman Gary, Liu Geoffrey, Mckay James D, Yuan Jian-Min, Field John K, Manjer Jonas, Grankvist Kjell, Kiemeney Lambertus A, Marchand Loic Le, Teare M Dawn, Schabath Matthew B, Johansson Mattias, Aldrich Melinda C, Davies Michael, Johansson Mikael, Tsao Ming-Sound, Caporaso Neil, Lazarus Philip, Lam Stephen, Bojesen Stig E, Arnold Susanne, Wu Xifeng, Zong Xuchen, Hong Yun-Chul, Ho Gloria Y F

Abstract excerpt

Obesity and cigarette smoking are correlated through complex relationships. Common genetic causes may contribute to these correlations. In this study, we selected 241 loci potentially associated with body mass index (BMI) based on the Genetic Investigation of ANthropometric Traits (GIANT) consortium data and calculated a BMI genetic risk score (BMI-GRS) for 17,037 individuals of European descent from the...

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PMID: 28957450
DOI: 10.1371/journal.pone.0185660
PMCID: PMC5619832

Genes

BDNF
ELAVL4
SGCZ
TMEM18

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