Article
Ligature-induced periodontitis promotes Dnmt3aR878H-driven clonal hematopoiesis.
Haematologica - 1 Jun 2026
Yuan Qiao, Liao Min, Zhuang Ziyao, Huang Chenyan, Chen Rixin, Song Yuxian, Wu Yu, Zou Peihui, Li Lili, Nie Hua, Zhang Miaomiao, Song Shiyuan, Li Yanfen, Yan Fuhua
Abstract excerpt
Characterized by somatic mutations (e.g., DNMT3A) in blood cells, clonal hematopoiesis (CH) is an age-related process wherein mutated hematopoietic stem and progenitor cells (HSPC) expand. This expansion thereby increases the risk of allcause mortality, myeloid hematologic malignancies and other non-malignant disorders, yet the risk factors that contribute to CH are still largely unknown. Periodontitis induces...
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