Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner.

doi:10.1093/cvr/cvae125

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Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner.

Cardiovascular research - 14 Oct 2024

Wang Yong, Li Guo, Chen Bingni, Shakir George, Volz Mario, van der Vorst Emiel P C, Maas Sanne L, Geiger Martina, Jethwa Carolin, Bartelt Alexander, Li Zhaolong, Wettich Justus, Sachs Nadja, Maegdefessel Lars, Nazari Jahantigh Maliheh, Hristov Michael, Lacy Michael, Lutz Beat, Weber Christian, Herzig Stephan, Guillamat Prats Raquel, Steffens Sabine

Abstract excerpt

AIMS: Although the cannabinoid CB1 receptor has been implicated in atherosclerosis, its cell-specific effects in this disease are not well understood. To address this, we generated a transgenic mouse model to study the role of myeloid CB1 signalling in atherosclerosis. METHODS AND RESULTS: Here, we report that male mice with myeloid-specific Cnr1 deficiency on atherogenic background developed smaller lesions and...

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PMID: 38838211
DOI: 10.1093/cvr/cvae125
PMCID: PMC11481387

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