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Article

IpaA reveals distinct modes of vinculin activation during Shigella invasion and cell-matrix adhesion.

Life science alliance - 1 Aug 2024

Cocom-Chan Benjamin, Khakzad Hamed, Konate Mahamadou, Aguilar Daniel Isui, Bello Chakir, Valencia-Gallardo Cesar, Zarrouk Yosra, Fattaccioli Jacques, Mauviel Alain, Javelaud Delphine, Tran Van Nhieu Guy

Abstract excerpt

Vinculin is a cytoskeletal linker strengthening cell adhesion. The Shigella IpaA invasion effector binds to vinculin to promote vinculin supra-activation associated with head-domain-mediated oligomerization. Our study investigates the impact of mutations of vinculin D1D2 subdomains' residues predicted to interact with IpaA VBS3. These mutations affected the rate of D1D2 trimer formation with distinct effects on...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38834194
DOI: 10.26508/lsa.202302418
PMCID: PMC11150655

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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