Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alteration of gene expression and protein solubility of the PI 5-phosphatase SHIP2 are correlated with Alzheimer’s disease pathology progression

1 Jun 2024

Abstract excerpt

A recent large genome-wide association study has identified EGFR (encoding the epidermal growth factor EGFR) as a new genetic risk factor for late-onset AD. SHIP2, encoded by INPPL1, is taking part in the signalling and interactome of several growth factor receptors, such as the EGFR. While INPPL1 has been identified as one of the most significant genes whose RNA expression correlates with cognitive decline, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Bioinformatics and Genomic Networks
Share to Protein Tyrosine Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38833073
DOI: 10.1007/s00401-024-02745-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alteration of gene expression and protein solubility of the PI 5-phosphatase SHIP2 are correlated with Alzheimer’s disease pathology progressionPMID 38833073Read ↗

INPP5D Expression is Associated with Risk for Alzheimer’s Disease and Induced by Plaque-Associated MicrogliaSemantic proximity Read ↗

<i>INPP5D</i> expression is associated with risk for Alzheimer’s disease and induced by plaque-associated microgliaSemantic proximity Read ↗

The Role of RIN3 Gene in Alzheimer’s Disease Pathogenesis: a Comprehensive ReviewSemantic proximity Read ↗

Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer’s diseaseSemantic proximity Read ↗

INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer’s Disease ModelsSemantic proximity Read ↗

Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer’s Disease-related endosomal and synaptic dysfunction with cholinergic neurodegenerationSemantic proximity Read ↗

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s diseaseSemantic proximity Read ↗

Expression of INPP5D Isoforms in Human Brain: Impact of Alzheimer's Disease Neuropathology and Genetics.Semantic proximity Read ↗

Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's diseaseSemantic proximity Read ↗

Functional sQTLs regulating PTK2B exon 31 splicing uncover an RNA-dependent modulation of its kinase activity and cellular phenotype.Semantic proximity Read ↗

Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.