Article

Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer’s Disease Models

2026-01-02

Abstract excerpt

<h4>ABSTRACT</h4> Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP1), encoded by the gene INPP5D, is a lipid phosphatase that negatively regulates immune receptor signaling in hematopoietic cells and microglia. Here, we describe a pyridyl-pyrazole-piperidine scaffold and the lead compound 3-((2-chlorobenzyl)oxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridine ( 32 ), which demonstrates SHIP1 target...

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Literature Corpus work: 9847d0c6-424e-5b0d-90c1-67ab286bcf53
DOI: 10.64898/2025.12.31.697127

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