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Article

Custom-Designed Probes for the Accurate Determination of Epidermal Growth Factor Receptor Mutations and Their Allelic Configuration.

Analytical chemistry - 18 Jun 2024

Li Jiaqi, Wang Chang, Zhao Songchen, Qi Lijuan, Yu Jingyuan, Hu Xintong, Chen Liguo, Sun Yi, Wang Duo, Jiang Yanfang, Du Yan

Abstract excerpt

The identification of single nucleotide polymorphisms (SNPs) is of paramount importance for disease diagnosis and clinical prognostication. In the context of nonsmall cell lung cancer (NSCLC), the emergence of resistance mutations, exemplified by the epidermal growth factor receptor (EGFR) T790 M and C797S, is intricately linked to the therapeutic efficacy of EGFR tyrosine kinase inhibitors (EGFR-TKIs). Herein, a...

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PMID: 38832555
DOI: 10.1021/acs.analchem.4c01771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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