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Article

Rapid detection of the epidermal growth factor receptor mutation in non-small-cell lung cancer for analysis of acquired resistance using molecular beacons.

The Journal of molecular diagnostics : JMD - 1 Sept 2010

Oh Young-Hee, Kim Youngwook, Kim Young-Pil, Seo Soo-Won, Mitsudomi Tetsuya, Ahn Myung-Ju, Park Keunchil, Kim Hak-Sung

Abstract excerpt

A secondary mutation (T790M) in epidermal growth factor receptor (EGFR) is a hallmark of acquired resistance to EGFR inhibitors used to treat non-small-cell lung cancer (NSCLC). Therefore, identifying the T790M mutation is crucial to guide treatment decisions. Given that DNA sequencing methods are time-consuming and insensitive, we developed and investigated the feasibility of using molecular beacons for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20805561
DOI: 10.2353/jmoldx.2010.090208
PMCID: PMC2928429

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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