Article
Deriving Mendelian Randomization-Based Causal Networks of Brain Imaging Phenotypes and Bipolar Disorder.
Biological psychiatry. Cognitive neuroscience and neuroimaging - 1 Jan 2026
O'Connell Shane, Brown Brielin C, Cannon Dara M, Broin Pilib Ó, Parker Nadine, Alnæs Dag, Westlye Lars T, Banerjee Saikat, Nabulsi Leila, Corley Emma, Andreassen Ole A, Knowles David A, Mullins Niamh
Abstract excerpt
BACKGROUND: Neuroanatomical variation in individuals with bipolar disorder (BD) has been described previously in observational studies. However, the causal dynamics of these relationships remain unexplored. METHODS: We performed Mendelian randomization (MR) of 297 structural and functional neuroimaging phenotypes from the UK Biobank and BD using genome-wide association study summary statistics. We carried out a...
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