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Article

Simultaneous Acquisition of T790M Mutation and SCLC Transformation during Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma: A Rare Case Report.

The American journal of case reports - 1 Jun 2024

Yazaki Tatsuya, Kimoto Masanobu, Minagawa Ayumi, Maruno Takashi, Yamanaka Miwa, Sonehara Kei, Hama Mineyuki, Nakamura Toshitsugu, Kanda Shintaro, Hanaoka Masayuki, Hachiya Tsutomu

Abstract excerpt

BACKGROUND Various resistance mechanisms of the epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) have been reported, and approximately half of the cases show a T790M point mutation as resistance to EGFR-TKI. In addition, 3-14% of cases of non-small cell lung cancer transform into small cell lung carcinoma (SCLC) during treatment. However, there are few reported cases in which 2 mechanisms of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38822519
DOI: 10.12659/AJCR.943466
PMCID: PMC11155200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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