Article
Sequential small cell transformation and T790M mutation in an epidermal growth factor-mutant lung adenocarcinoma: A rare occurrence with significant management implications.
Cytopathology : official journal of the British Society for Clinical Cytology - 1 Nov 2022
Shastri Malvika, Gupta Parikshaa, Gupta Nalini, Singh Navneet, Bal Amanjit, Srinivasan Radhika, Khosla Divya
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) resistance may be acquired via genotypic and/or phenotypic transformations. Herein, we report an extremely uncommon case with sequential small cell transformation and EGFR T790M mutation, in an elderly female with EGFR exon 21 L858R-mutant lung adenocarcinoma, following treatment with a first-generation EGFR-TKI. CASE: A...
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